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Classic fifth disease, aplastic crisis, and PPGSS are caused almost exclusively by parvovirus B19.
This virus, distributed worldwide, infects only humans.
Transmission occurs via vertical transmission (birth), large droplet respiratory secretions, transfusion of blood products, and percutaneous exposure to blood.
David J Cennimo, MD, FAAP, FACP, AAHIVS Assistant Professor of Medicine and Pediatrics, Adult and Pediatric Infectious Diseases, Rutgers New Jersey Medical School; Hospital Epidemiologist and Co-Director of Antimicrobial Stewardship, University Hospital David J Cennimo, MD, FAAP, FACP, AAHIVS is a member of the following medical societies: American Academy of HIV Medicine, American Academy of Pediatrics, American College of Physicians, American Medical Association, HIV Medicine Association, Infectious Diseases Society of America, Medical Society of New Jersey, Pediatric Infectious Diseases Society Disclosure: Nothing to disclose.
You can reduce your chance of being infected with parvovirus B19 or infecting others by All healthcare providers and patients should strictly follow the infection control practices listed above to prevent parvovirus B19 from spreading.
For information about handwashing, see CDC’s Clean Hands Save Lives!
Common symptoms of parvovirus B19 (B19V) infection include a mild nonspecific prodromal illness that may consist of fever (15-30% of patients), malaise, headache, myalgia, nausea, and rhinorrhea; typically beginning 5-7 days after initial infection.
A diffuse maculopapular rash can appear 1-4 days later and fades to a lacy erythematous rash, which may be pruritic and may spread gradually toward the distal extremities.
This rash is the most recognized feature of fifth disease. Some people may get a second rash a few days later on their chest, back, buttocks, or arms and legs.Most seropositive patients have no history of this classic biphasic illness.The clinical symptoms widely vary, and the classic "slapped cheek" rash is much more common in young children.Fifth disease is a mild rash illness caused by parvovirus B19. A person usually gets sick with fifth disease within four to 14 days after getting infected with parvovirus B19.This disease, also called erythema infectiosum, got its name because it was fifth in a list of historical classifications of common skin rash illnesses in children.